The Cancer Dependency Map enables drug mechanism‐of‐action investigations
نویسندگان
چکیده
منابع مشابه
Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.
A new type of signaling network element, called cancer signaling bridges (CSB), has been shown to have the potential for systematic and fast-tracked drug repositioning. On the basis of CSBs, we developed a computational model to derive specific downstream signaling pathways that reveal previously unknown target-disease connections and new mechanisms for specific cancer subtypes. The model enabl...
متن کاملOrthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates
A strategy for the preparation of homogeneous antibody-drug conjugates (ADCs) containing multiple payloads has been developed. This approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable site-specific conjugation of each drug. In addition, because the approach utilizes conjugation to native antibody cysteine residues, it is widely applicable and enables...
متن کاملExtraction of Drug-Drug Interaction from Literature through Detecting Linguistic-based Negation and Clause Dependency
Extracting biomedical relations such as drug-drug interaction (DDI) from text is an important task in biomedical NLP. Due to the large number of complex sentences in biomedical literature, researchers have employed some sentence simplification techniques to improve the performance of the relation extraction methods. However, due to difficulty of the task, there is no noteworthy improvement in t...
متن کاملDependency Map of Proteins in the Small Ribosomal Subunit
The assembly of the ribosome has recently become an interesting target for antibiotics in several bacteria. In this work, we extended an analytical procedure to determine native state fluctuations and contact breaking to investigate the protein stability dependence in the 30S small ribosomal subunit of Thermus thermophilus. We determined the causal influence of the presence and absence of prote...
متن کاملInvestigations on Armstrong Relations , Dependency Inference , andExcluded Functional
This paper rst presents some new results on excluded functional dependencies, i.e., FDs which do not hold on a given relation schema. In particular, we show how excluded dependencies relate to Armstrong relations, and we state criteria for deciding whether a set of excluded dependencies characterizes a set of FDs. In the rest of the paper, complexity issues related to the following three proble...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2020
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20209757